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“Master of my domain” became a part of the American lexicon from this episode. Nk,[167] “So Happy I Could Die” by Lady Gaga, “Masturbating Jimmy” by The Tiger Lillies, “When Life Gets Boring” by Gob, “Daybed” by FKA Twigs, “Get a Grip” by Semisonic, and “Darling Nikki” by Prince. The 1983 recording “She Bop” by Cyndi Lauper was one of the first fifteen songs ever required to carry a Parental Advisory sticker for sexual content.[168] In a 1993 interview on The Howard Stern Show, Lauper claimed she recorded the vocal track in the nude.[169] The song “Masturbates” by rock group Mindless Self Indulgence also deals with the concept of auto-erotic activity in a punk framework. Masturbation aids such as a vibrator, dildo, or Ben Wa balls can also be used to stimulate the vagina and clitoris. Many women caress their breasts or stimulate a nipple with the free hand and anal stimulation is also enjoyed by some. Personal lubricant is sometimes used during masturbation, especially when penetration is involved, but this is not universal and many women find their natural lubrication sufficient.

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In particular, a dramatic increase in publications began in the mid-1990s, which may be attributable to several influential review articles along with other events occurring in the 1990s that drew considerable attention to the topic. In 1992, an important publication by Karen Berkley32 highlighted the importance of sex-related issues in neuroscience research. Thus, the early to mid-1990s was a period of increased scholarly activity regarding sex differences in pain. Another neurotransmitter system that could contribute to sex differences in pain responses is the dopaminergic system.

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More research is needed to further characterize the contribution of gender roles to the relationship between sex, gender, and pain. The results from 22 studies that examined sex differences in experimental heat pain are presented in the upper portion of Table 6. All of the studies used some form of contact heat with the exception of one study that used hot water immersion.360 Also, the forearm was the most common site for stimulus application. The vast majority of studies reported that females were more sensitive to heat pain than males. For the studies examining behavioral measures of heat pain sensitivity, 81% (12/17), and 94% (15/16) of the studies reported lower thresholds and tolerances, respectively, in females. Females were also found to rate heat pain as more intense and unpleasant in the majority of studies that included a suprathreshold protocol (7/9, 78%), and one study found that females required lower temperatures to evoke moderate pain.411 Overall, the hypothesis that heat pain sensitivity differs as a function of sex has been supported.

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  • Average annual percentage increase in publications over each 2-year period after 1980, which served as the reference year.
  • In the final and rate limiting step, the C17 keto group androstenedione is reduced by 17Ξ²-hydroxysteroid dehydrogenase to yield testosterone.
  • However, the results of a recent study suggested that duplication of SOX9 is not a common cause of 46,XX testicular or 46,XX ovotesticular DSD8).
  • Cognitive/affective factors are important determinants of pain responses and likely contribute to sex differences in pain.289,335 The cognitive and affective mechanisms that have been investigated most widely in the context of sex and gender differences include coping processes, catastrophizing, and affective factors (eg, anxiety, depression).
  • A study that assessed pain in patients who underwent arthroscopic anterior cruciate ligament (ACL) reconstruction at an outpatient facility in the United States did not find sex differences in pain at the immediate postoperative evaluation.398 However, on the first day after surgery, females had higher mean VAS pain scores than males.

Riley and colleagues326 found that for most orofacial pain symptoms, significant sex differences in pain ratings were found within the middle aged (45- to 64-year-old) cohort but not the older (65+) group. A Dirty Talk AI is an AI-powered chatbot that allows users to engage in a realistic sexting experience to its users beyond traditional AI chat applications. Dirty Talk AI allows users to indulge in naughty conversations with AI characters and send text messages expressing their desires and fantasies. Taken together, these findings from studies of musculoskeletal pain indicate that regardless of site or time frame, females consistently are more likely to report musculoskeletal pain than males, though these differences may be less consistent for low back pain. There is limited evidence for increased pain intensity among women with the possible exception of OA, where greater pain severity among women is more common. There is limited evidence that women with musculoskeletal pain are more likely to be depressed than men.

The findings appear to indicate that females exhibited an increase in their pain tolerance when given the expectation that women would tolerate the pain for a longer time, whereas males showed similar pain tolerance regardless of expected tolerance time. Another study examined the effects of high versus low monetary incentives on pain tolerance among females and males, anticipating that high external incentives would produce stronger effects among females, because males possess higher endogenous motivation to tolerate pain.257 However, the incentive manipulation had no effect on pain tolerance for females or males. In addition to the above findings addressing sex differences in responses to ΞΌ-opioid agonists, others have investigated analgesic responses to mixed-action opioid agonist-antagonists among women relative to men.


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